GDF1 explained

Growth differentiation factor 1 (GDF1) is a protein that in humans is encoded by the GDF1 gene.^[1]

GDF1 belongs to the transforming growth factor beta superfamily that has a role in left-right patterning and mesoderm induction during embryonic development.^[2] It is found in the brain, spinal cord and peripheral nerves of embryos.^{[1] [2]}

Further reading

• Jiang JC, Kirchman PA, Zagulski M . Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. . Genome Res. . 8 . 12 . 1259–72 . 1998 . 9872981 . 10.1101/gr.8.12.1259. etal. free .
• Lee SJ . Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily. . Mol. Endocrinol. . 4 . 7 . 1034–40 . 1990 . 1704486 . 10.1210/mend-4-7-1034 . free .
• Li J, Jia H, Xie L . Correlation of inhibitor of differentiation 1 expression to tumor progression, poor differentiation and aggressive behaviors in cervical carcinoma. . Gynecol. Oncol. . 114 . 1 . 89–93 . 2009 . 19359031 . 10.1016/j.ygyno.2009.03.016 . etal.
• Ducy P, Karsenty G . The family of bone morphogenetic proteins. . Kidney Int. . 57 . 6 . 2207–14 . 2000 . 10844590 . 10.1046/j.1523-1755.2000.00081.x . free .
• Lee SJ . Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure. . Proc. Natl. Acad. Sci. U.S.A. . 88 . 10 . 4250–4 . 1991 . 2034669 . 10.1073/pnas.88.10.4250. 51636 . 1991PNAS...88.4250L . free .
• Roessler E, Pei W, Ouspenskaia MV . Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly. . Mol. Genet. Metab. . 98 . 1–2 . 225–34 . 2009. 19553149 . 10.1016/j.ymgme.2009.05.005 . 2774839 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Grimwood J, Gordon LA, Olsen A . The DNA sequence and biology of human chromosome 19. . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . etal. free .
• Karkera JD, Lee JS, Roessler E . Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans. . Am. J. Hum. Genet. . 81 . 5 . 987–94 . 2007 . 17924340 . 10.1086/522890 . 2265655 . etal.
• Polymeropoulos MH, Xiao H, Sikela JM . Chromosomal distribution of 320 genes from a brain cDNA library. . Nat. Genet. . 4 . 4 . 381–6 . 1993 . 8401586 . 10.1038/ng0893-381 . 33426184 . etal.

Notes and References

1. Lee SJ . Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure . Proc. Natl. Acad. Sci. U.S.A. . 88 . 10 . 4250–4 . May 1991 . 2034669 . 51636 . 10.1073/pnas.88.10.4250. 1991PNAS...88.4250L . free .
2. Rankin CT, Bunton T, Lawler AM, Lee SJ . Regulation of left-right patterning in mice by growth/differentiation factor-1 . Nat. Genet. . 24 . 3 . 262–5 . March 2000 . 10700179 . 10.1038/73472 . 6787053 .