Gregatin B Explained

Gregatin B is a metabolite of the fungi Cephalosporium gregatum and Aspergillus panamensis with the molecular formula C₁₄H₁₈O₄^{[1] [2]} Gregatin B is a weak antibiotic.^{[3] [2]} Gregatin B was discovered in 1982^[2] and has been the subject of total synthesis.^{[4] [5]}

Further reading

• Wijeratne . E. M. Kithsiri . Xu . Yaming . Arnold . A. Elizabeth . Gunatilaka . A. A. Leslie . Pulvinulin A, Graminin C, and cis-Gregatin B – New Natural Furanones from Pulvinula sp. 11120, a Fungal Endophyte of Cupressus arizonica . Natural Product Communications . January 2015 . 10 . 1 . 1934578X1501000 . 10.1177/1934578x1501000127 . 39340804 . 1934-578X. free .
• Burghart-Stoll . H . Brückner . R . A serendipitous synthesis of (+)-gregatin B, second structure revisions of the aspertetronins, gregatins, and graminin A, structure revision of the penicilliols. . Organic Letters . 20 May 2011 . 13 . 10 . 2730–3 . 10.1021/ol2008318 . 21526752.
• Book: Peberdy . John F. . Penicillium and Acremonium . 11 November 2013 . Springer Science & Business Media . 978-1-4899-1986-1 . 222 . en.

Notes and References

1. Book: Durbin . R. . Toxins in Plant Disease . 2 December 2012 . Elsevier . 978-0-323-14704-0 . 410 . en.
2. Book: Buckingham . John . Dictionary of Organic Compounds . 1987 . Taylor & Francis . 978-0-412-17050-8 . 367 . en.
3. Book: Bycroft . Barrie W. . Payne . David J. . Dictionary of Antibiotics and Related Substances: with CD-ROM, Second Edition . 9 August 2013 . CRC Press . 978-1-4822-8215-3 . 892 . en.
4. Gregatin B Chemical Substance Information J-GLOBAL . Jglobal.JST.go.jp . en.
5. Kusakabe . Taichi . Kawai . Yasuko . Kato . Keisuke . Total Synthesis of (+)-Gregatin B and E . Organic Letters . 4 October 2013 . 15 . 19 . 5102–5105 . 10.1021/ol402472q. 24066736 .