Gossypetin Explained
Gossypetin, also known as 3,5,7,8,3',4'-hexahydroxyflavone, is a flavonol, a type of flavonoid. It has been isolated from the flowers and the calyx of Hibiscus sabdariffa (roselle) and exhibits a strong antibacterial activity.[1] [2] The compound has also been found to act as an antagonist of TrkB.[3] Gossypetin has radioprotective activity.
The enzyme 8-hydroxyquercetin 8-O-methyltransferase uses S-adenosyl methionine and gossypetin to produce S-adenosylhomocysteine and 3,5,7,3',4'-pentahydroxy-8-methoxyflavone.
In 2022, a study in an animal model using intragastric administration suggested that the flavonoid gossypetin facilitated the clearance of beta-amyloid in the brain and is a promising target for the study of treatments for Alzheimer's Disease by enhancing microglial phagocytic activity against Aβ.[4]
See also
- Tropomyosin receptor kinase B § Antagonists
Notes and References
- Web site: Antibacterial activity of gossypetin isolated from hibiscus sabdariffa . 2008-04-23 . 2007-12-05 . https://web.archive.org/web/20071205051151/http://medind.nic.in/imvw/imvw289.html . dead .
- Amitava Khan, Krishnendu Manna, Chinchubose, Mahuya Sinha, Dipesh Kr Das, Swaraj Bandhu Kesh, Anindita Chakrabarty, Asoke Banerji & Sanjit Dey: Gossypetin, a naturally occurring hexahydroxy flavones ameliorates gamma radiation mediated DNA damage International Journal of Radiation Biology (2013):89(11): 965-975.
- Obianyo. Obiamaka. Ye. Keqiang. Novel small molecule activators of the Trk family of receptor tyrosine kinases. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1834. 10. 2013. 2213–2218. 1570-9639. 10.1016/j.bbapap.2012.08.021. 3602283. 22982231.
- Jo, K.W., Lee, D., Cha, D.G. et al., Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ, Alzheimer's Research & Therapy, October 21, 2022 - Alz Res Therapy 14, 158 (2022)
