Glyoxylate dehydrogenase (acylating) explained

glyoxylate dehydrogenase (acylating)
Ec Number:1.2.1.17
Cas Number:9028-96-0
Go Code:0047968

In enzymology, a glyoxylate dehydrogenase (acylating) is an enzyme that catalyzes the chemical reaction

glyoxylate + CoA + NADP+

\rightleftharpoons

oxalyl-CoA + NADPH + H+

The 3 substrates of this enzyme are glyoxylate, CoA, and NADP+, whereas its 3 products are oxalyl-CoA, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glyoxylate:NADP+ oxidoreductase (CoA-oxalylating). This enzyme participates in glyoxylate and dicarboxylate metabolism.

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