Hydroxyacylglutathione hydrolase explained

Hydroxyacylglutathione hydrolase
Ec Number:	3.1.2.6

The enzyme hydroxyacylglutathione hydrolase (EC 3.1.2.6, systematic name = S-(2-hydroxyacyl)glutathione hydrolase) catalyzes the following reaction:^[1]

S-(2-hydroxyacyl)glutathione + H₂O = glutathione + a 2-hydroxy carboxylate

This enzyme belongs to the family of hydrolases, specifically the class of thioester lyases. It is commonly known as glyoxalase II. It participates in pyruvate metabolism.

References

• Ball JC, Vander Jagt DL . Purification of S-2-hydroxyacylglutathione hydrolase (glyoxalase II) from rat erythrocytes . Anal. Biochem. . 98 . 2 . 472–7 . 1979 . 496013 . 10.1016/0003-2697(79)90169-6.

Notes and References

1. Vander Jagt DL . Glyoxalase II: molecular characteristics, kinetics and mechanism . Biochem. Soc. Trans. . 21 . 2 . 522–7 . 1993 . 8359524 . 10.1042/bst0210522.