Glycosylphosphatidylinositol phospholipase D explained

Glycosylphosphatidylinositol phospholipase D
Ec Number:	3.1.4.50
Cas Number:	113756-14-2

Glycosylphosphatidylinositol phospholipase D (EC 3.1.4.50, GPI-PLD, glycoprotein phospholipase D, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D) is an enzyme with systematic name glycoprotein-phosphatidylinositol phosphatidohydrolase.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myoinositol + H₂O

\rightleftharpoons 6-(α-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate

This enzyme cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors.

See also

• Phospholipase

Notes and References

1. Low MG, Prasad AR . A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma . Proceedings of the National Academy of Sciences of the United States of America . 85 . 4 . 980–4 . February 1988 . 3422494 . 279684 . 10.1073/pnas.85.4.980 . 1988PNAS...85..980L . free .
2. Malik AS, Low MG . Conversion of human placental alkaline phosphatase from a high M_r form to a low M_r form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases . The Biochemical Journal . 240 . 2 . 519–27 . December 1986 . 10.1042/bj2400519 . 3028377 . 1147446 .
3. Li JY, Hollfelder K, Huang KS, Low MG . Structural features of GPI-specific phospholipase D revealed by proteolytic fragmentation and Ca²⁺ binding studies . The Journal of Biological Chemistry . 269 . 46 . 28963–71 . November 1994 . 10.1016/S0021-9258(19)62000-4 . 7961859 . free .
4. Deeg MA, Bierman EL, Cheung MC . GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex . Journal of Lipid Research . 42 . 3 . 442–51 . March 2001 . 10.1016/S0022-2275(20)31669-2 . 11254757 . free .