Glycoprotein endo-alpha-1,2-mannosidase explained

Glycoprotein endo-α-1,2-mannosidase
Ec Number:	3.2.1.130
Cas Number:	108022-16-8

Glycoprotein endo-α-1,2-mannosidase (glucosylmannosidase, endo-α-D-mannosidase, endo-α-mannosidase, endomannosidase, glucosyl mannosidase) is an enzyme with systematic name glycoprotein glucosylmannohydrolase.^{[1] [2]} It catalyses the hydrolysis of the terminal α-D-glucosyl-(1,3)-D-mannosyl unit from the GlcMan₉(GlcNAc)₂ oligosaccharide component of the glycoprotein produced in the Golgi membrane.

This protein is involved in the synthesis of glycoproteins.

See also

• MANEA

Notes and References

1. Lubas WA, Spiro RG . Golgi endo-α-D-mannosidase from rat liver, a novel N-linked carbohydrate unit processing enzyme . The Journal of Biological Chemistry . 262 . 8 . 3775–81 . March 1987 . 3818665 .
2. Tulsiani DR, Coleman VD, Touster O . Asparagine-linked glycoprotein biosynthesis in rat brain: identification of glucosidase I, glucosidase II, and endomannosidase (glucosyl mannosidase) . Archives of Biochemistry and Biophysics . 277 . 1 . 114–21 . February 1990 . 2407194 . 10.1016/0003-9861(90)90558-g . Oscar Touster .