Glycoprotein 6-alpha-L-fucosyltransferase explained
| glycoprotein 6-alpha-L-fucosyltransferase |
| Ec Number: | 2.4.1.68 |
| Cas Number: | 9033-08-3 |
| Go Code: | 0008424 |
In enzymology, a glycoprotein 6-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction
GDP-L-fucose + N4-asparagine
GDP + N
4-
asparagine
The 2 substrates of this enzyme are GDP-L-fucose and N4-asparagine, and its 2 products are GDP and N4-asparagine.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-asparagine) 6-alpha-L-fucosyltransferase. Other names in common use include GDP-fucose-glycoprotein fucosyltransferase, GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1->6fucosyltransferase, GDP-L-fucose-glycoprotein fucosyltransferase, glycoprotein fucosyltransferase, guanosine diphosphofucose-glycoprotein fucosyltransferase, GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked, N-acetylglucosamine of, 4-N-asparagine) 6-alpha-L-fucosyltransferase, and FucT. This enzyme participates in 3 metabolic pathways: n-glycan biosynthesis, keratan sulfate biosynthesis, and glycan structures - biosynthesis 1.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes,, and .
References
- Longmore GD, Schachter H . 1982 . Product-identification and substrate-specificity studies of the GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside (FUC goes to Asn-linked GlcNAc) 6-alpha-L-fucosyltransferase in a Golgi-rich fraction from porcine liver . Carbohydr. Res. . 100 . 365 - 92 . 7083256 . 10.1016/S0008-6215(00)81049-6 .
- Voynow JA, Scanlin TF, Glick MC . 1988 . A quantitative method for GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha 1--6fucosyltransferase activity with lectin affinity chromatography . Anal. Biochem. . 168 . 367 - 73 . 3364733 . 10.1016/0003-2697(88)90331-4 . 2 .
- Teshima T, Fujii S, Shiba T, Taniguchi N . 1996 . Purification and cDNA cloning of porcine brain GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1-->6fucosyltransferase . J. Biol. Chem. . 271 . 27810 - 7 . 8910378 . 10.1074/jbc.271.44.27810 . 44 . free .
