Glycoprotein 3-alpha-L-fucosyltransferase explained
| glycoprotein 3-alpha-L-fucosyltransferase |
| Ec Number: | 2.4.1.214 |
| Cas Number: | 68247-53-0 |
| Go Code: | 0018392 |
In enzymology, a glycoprotein 3-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction
GDP-L-fucose + N4-asparagine
GDP + N
4-
asparagine
The 5 substrates of this enzyme are GDP-L-fucose, products]] are GDP, systematic name]] of this enzyme class is GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-asparagine) 3-alpha-L-fucosyl-transferase. Other names in common use include GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase, GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase, GDP-fucose:beta-N-acetylglucosamine (Fuc to, (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase, GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked, N-acetylglucosamine of, 4-N-asparagine) 3-alpha-L-fucosyl-transferase. This enzyme participates in glycan structures - biosynthesis 1.
References
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- Fabini G, Freilinger A, Altmann F, Wilson IB . 2001 . Identification of core alpha 1,3-fucosylated glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster Potential basis of the neural anti-horseadish peroxidase epitope . J. Biol. Chem. . 276 . 28058 - 67 . 11382750 . 10.1074/jbc.M100573200 . 30 . free .
- Leiter H, Mucha J, Staudacher E, Grimm R, Glossl J, Altmann F . 1999 . Purification, cDNA cloning, and expression of GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase from mung beans . J. Biol. Chem. . 274 . 21830 - 9 . 10419500 . 10.1074/jbc.274.31.21830 . 31 . free .
- van Tetering A, Schiphorst WE, van den Eijnden DH, van Die I . 1999 . Characterization of a core alpha1-->3-fucosyltransferase from the snail Lymnaea stagnalis that is involved in the synthesis of complex-type N-glycans . FEBS Lett. . 461 . 311 - 4 . 10567717 . 10.1016/S0014-5793(99)01489-1 . 3 . free .
- Staudacher E, Altmann F, Glössl J, März L, Schachter H, Kamerling JP, Hård K, Vliegenthart JF . 1991 . GDP-fucose: beta-N-acetylglucosamine (Fuc to (Fuc alpha 1--6GlcNAc)-Asn-peptide)alpha 1--3-fucosyltransferase activity in honeybee (Apis mellifica) venom glands. The difucosylation of asparagine-bound N-acetylglucosamine . Eur. J. Biochem. . 199 . 745 - 51 . 1868856 . 10.1111/j.1432-1033.1991.tb16179.x . 3 . free .
