Glycochenodeoxycholate sulfotransferase explained

Glycochenodeoxycholate sulfotransferase
Ec Number:	2.8.2.34

In enzymology, a glycochenodeoxycholate sulfotransferase is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + glycochenodeoxycholate

\rightleftharpoons adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and glycochenodeoxycholate, whereas its two products are adenosine 3',5'-bisphosphate and glycochenodeoxycholate 7-sulfate.

Nomenclature

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase. Other names in common use include bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase, bile acid:PAPS:sulfotransferase, and BAST.

Further reading

• Barnes S, Burhol PG, Zander R, Haggstrom G, Settine RL, Hirschowitz BI . Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters . Journal of Lipid Research . 20 . 8 . 952–9 . November 1979 . 533830 .
• Russell DW . The enzymes, regulation, and genetics of bile acid synthesis . Annual Review of Biochemistry . 72 . 137–74 . 2003 . 12543708 . 10.1146/annurev.biochem.72.121801.161712 .