Glycine reuptake inhibitor explained

A glycine reuptake inhibitor (GRI) is a type of drug which inhibits the reuptake of the neurotransmitter glycine by blocking one or more of the glycine transporters (GlyTs). Examples of GRIs include bitopertin (RG1678), iclepertin (BI-425809), ORG-24598, ORG-25935, ALX-5407, and sarcosine, which are selective GlyT1 blockers, and ORG-25435 and N-arachidonylglycine, which are selective GlyT2 blockers.^{[1] [2]} Some weak and/or non-selective GlyT blockers include amoxapine and ethanol (alcohol).^[3]

See also

• Reuptake inhibitor
• Glycinergic
• GABA reuptake inhibitor
• Excitatory amino acid reuptake inhibitor

Notes and References

1. Harsing LG, Juranyi Z, Gacsalyi I, Tapolcsanyi P, Czompa A, Matyus P . Glycine transporter type-1 and its inhibitors . Curr. Med. Chem. . 13 . 9 . 1017–44 . 2006 . 16611082 . 10.2174/092986706776360932 .
2. Harvey RJ, Yee BK . Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain . Nat Rev Drug Discov . 12 . 11 . 866–85 . November 2013 . 24172334 . 10.1038/nrd3893 . 28022131 .
3. Book: Harald Sitte. Michael Freissmuth. Neurotransmitter Transporters. 2 August 2006. Springer Science & Business Media. 978-3-540-29784-0. 472–.