Glycine reuptake inhibitor explained

A glycine reuptake inhibitor (GRI) is a type of drug which inhibits the reuptake of the neurotransmitter glycine by blocking one or more of the glycine transporters (GlyTs). Examples of GRIs include bitopertin (RG1678), Org 24598, Org 25935, ALX-5407, and sarcosine, which are selective GlyT1 blockers, and Org 25543 and N-arachidonylglycine, which are selective GlyT2 blockers.^{[1] [2]} Some weak and/or non-selective GlyT blockers include amoxapine and ethanol (alcohol).^[3]

See also

• Reuptake inhibitor
• Glycinergic
• GABA reuptake inhibitor
• Excitatory amino acid reuptake inhibitor

Notes and References

1. Harsing LG, Juranyi Z, Gacsalyi I, Tapolcsanyi P, Czompa A, Matyus P . Glycine transporter type-1 and its inhibitors . Curr. Med. Chem. . 13 . 9 . 1017–44 . 2006 . 16611082 . 10.2174/092986706776360932 .
2. Harvey RJ, Yee BK . Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain . Nat Rev Drug Discov . 12 . 11 . 866–85 . November 2013 . 24172334 . 10.1038/nrd3893 . 28022131 .
3. Book: Harald Sitte. Michael Freissmuth. Neurotransmitter Transporters. 2 August 2006. Springer Science & Business Media. 978-3-540-29784-0. 472–.