Glycine dehydrogenase (cyanide-forming) explained

glycine dehydrogenase (cyanide-forming)
Ec Number:	1.4.99.5
Go Code:	0050622

In enzymology, a glycine dehydrogenase (cyanide-forming) is an enzyme that catalyzes the chemical reaction

glycine + 2 A

\rightleftharpoons hydrogen cyanide + CO₂ + 2 AH₂

Thus, the two substrates of this enzyme are glycine and A, whereas its 3 products are hydrogen cyanide, CO₂, and AH₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with other acceptors. The systematic name of this enzyme class is glycine:acceptor oxidoreductase (hydrogen-cyanide-forming). Other names in common use include hydrogen cyanide synthase, and HCN synthase.

References

• Wissing F . 1975 . Cyanide production from glycine by a homogenate from a Pseudomonas species . J. Bacteriol. . 121 . 695 - 9 . 234422 . 2 . 245984 .
• Castric PA . 1977 . Glycine metabolism by Pseudomonas aeruginosa: hydrogen cyanide biosynthesis . J. Bacteriol. . 130 . 826 - 31 . 233722 . 2 . 235287 .
• Haas D . 1998 . Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0 . J. Bacteriol. . 180 . 3187 - 96 . 9620970 . Blumer . C . Von Schroetter . C . Gaia . V . Défago . G . Keel . C . Haas . D . 12 . 107821 .
• Blumer C, Haas D . 2000 . Mechanism, regulation, and ecological role of bacterial cyanide biosynthesis . Arch. Microbiol. . 173 . 170 - 7 . 10763748 . 10.1007/s002039900127 . 3 .