glycerol kinase | |
Hgncid: | 4289 |
Symbol: | GK |
Entrezgene: | 2710 |
Omim: | 300474 |
Refseq: | NM_000167 |
Uniprot: | P32189 |
Ecnumber: | 2.7.1.30 |
Chromosome: | X |
Arm: | p |
Band: | 21.3 |
Glycerol kinase, encoded by the gene GK, is a phosphotransferase enzyme involved in triglycerides and glycerophospholipids synthesis.
Glycerol kinase catalyzes the transfer of a phosphate from ATP to glycerol thus forming glycerol 3-phosphate:
ATP + glycerol <=> ADP + sn-glycerol 3-phosphate
Adipocytes lack glycerol kinase so they cannot metabolize the glycerol produced during triacyl glycerol degradation. This glycerol is instead shuttled to the liver via the blood where it is:
This protein may use the morpheein model of allosteric regulation.[1]
Glycerol Kinase (alternative name, ATP:glycerol 3-phosphotransferase or Glycerokinase) adopts a ribonuclease H-like fold consisting of an alpha-beta 2-layer sandwich of CATH family 3.30.420.40., there were 20 structures of this protein in the PDB, most of which are homodimeric.