Glycerol-3-phosphate dehydrogenase (NAD(P)+) explained

glycerol-3-phosphate dehydrogenase [NAD(P)<sup>+</sup>]
Ec Number:	1.1.1.94
Cas Number:	37250-30-9
Go Code:	0047952

In enzymology, a glycerol-3-phosphate dehydrogenase [NAD(P)⁺] is an enzyme that catalyzes the chemical reaction

sn-glycerol 3-phosphate + NAD(P)⁺

\rightleftharpoons glycerone phosphate + NAD(P)H + H⁺

The 3 substrates of this enzyme are sn-glycerol 3-phosphate, NAD⁺, and NADP⁺, whereas its 4 products are glycerone phosphate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:NAD(P)⁺ 2-oxidoreductase. Other names in common use include L-glycerol-3-phosphate:NAD(P)⁺ oxidoreductase, glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide, (phosphate)), glycerol 3-phosphate dehydrogenase (NADP⁺), and glycerol-3-phosphate dehydrogenase [NAD(P)⁺]. This enzyme participates in glycerophospholipid metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Kito M, Pizer LI . 1969 . Purification and regulatory properties of the biosynthetic L-glycerol 3-phosphate dehydrogenase from Escherichia coli . J. Biol. Chem. . 244 . 3316 - 23 . 4389388 . 12 .
• Edgar JR, Bell RM . 1978 . Biosynthesis in Escherichia coli of sn-glycerol 3-phosphate, a precursor of phospholipid . J. Biol. Chem. . 253 . 6348 - 53 . 355254 . 18 .
• Edgar JR, Bell RM . 1978 . Biosynthesis in Escherichia coli of sn-glycerol 3-phosphate, a precursor of phospholipid. Kinetic characterization of wild type and feedback-resistant forms of the biosynthetic sn-glycerol-3-phosphate dehydrogenase . J. Biol. Chem. . 253 . 6354 - 63 . 28326 . 18 .
• Edgar JR, Bell RM . 1980 . Biosynthesis in Escherichia coli of sn-glycerol-3-phosphate, a precursor of phospholipid. Further kinetic characterization of wild type and feedback-resistant forms of the biosynthetic sn-glycerol-3-phosphate dehydrogenase . J. Biol. Chem. . 255 . 3492 - 7 . 6767719 . 8 .