Glycerol-3-phosphate 1-dehydrogenase (NADP+) explained

glycerol-3-phosphate 1-dehydrogenase (NADP^+)
Ec Number:	1.1.1.177
Cas Number:	37213-46-0
Go Code:	0047014

In enzymology, a glycerol-3-phosphate 1-dehydrogenase (NADP⁺) is an enzyme that catalyzes the chemical reaction

sn-glycerol 3-phosphate + NADP⁺

\rightleftharpoons D-glyceraldehyde 3-phosphate + NADPH + H⁺

Thus, the two substrates of this enzyme are sn-glycerol 3-phosphate and NADP⁺, whereas its 3 products are D-glyceraldehyde 3-phosphate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:NADP⁺ 1-oxidoreductase. Other names in common use include glycerol phosphate (nicotinamide adenine dinucleotide phosphate), dehydrogenase, L-glycerol 3-phosphate:NADP⁺ oxidoreductase, glycerin-3-phosphate dehydrogenase, NADPH-dependent glycerin-3-phosphate dehydrogenase, and glycerol-3-phosphate 1-dehydrogenase (NADP⁺).

References

• Glushankov PE, Epifanova VE, Kolotilova AI . 1976 . Pentose phosphate pathway of carbohydrate metabolism and NADP-dependent glycerol 3-phosphate dehydrogenase activity in some white rat tissues . Biokhimiya . 41 . 1788 - 1790 .
• Wood T . 1974 . Catalysis of pentose phosphate pathway reactions by cytoplasmic fractions from muscle, uterus and liver of the rat, and the presence of a reduced nicotinamide-adenine dinucleotide phosphate-triose phosphate oxidoreductase in rat muscle . Biochem. J. . 138 . 71 - 6 . 4152128 . 1 . 1166176 .