Glycerate 2-kinase explained

Glycerate 2-kinase
Ec Number:	2.7.1.165

Glycerate 2-kinase (D-glycerate-2-kinase, glycerate kinase (2-phosphoglycerate forming), ATP:(R)-glycerate 2-phosphotransferase) is an enzyme with systematic name ATP:D-glycerate 2-phosphotransferase.^{[1] [2] [3] [4] [5] [6]} This enzyme catalyses the following chemical reaction

\rightleftharpoons ADP + 2-phospho-D-glycerate

A key enzyme in the nonphosphorylative Entner-Doudoroff pathway in archaea.

Notes and References

1. Liu B, Wu L, Liu T, Hong Y, Shen Y, Ni J . A MOFRL family glycerate kinase from the thermophilic crenarchaeon, Sulfolobus tokodaii, with unique enzymatic properties . Biotechnology Letters . 31 . 12 . 1937–41 . December 2009 . 19690808 . 10.1007/s10529-009-0089-z .
2. Reher M, Bott M, Schönheit P . Characterization of glycerate kinase (2-phosphoglycerate forming), a key enzyme of the nonphosphorylative Entner-Doudoroff pathway, from the thermoacidophilic euryarchaeon Picrophilus torridus . FEMS Microbiology Letters . 259 . 1 . 113–9 . June 2006 . 16684110 . 10.1111/j.1574-6968.2006.00264.x . free .
3. Liu B, Hong Y, Wu L, Li Z, Ni J, Sheng D, Shen Y . A unique highly thermostable 2-phosphoglycerate forming glycerate kinase from the hyperthermophilic archaeon Pyrococcus horikoshii: gene cloning, expression and characterization . Extremophiles . 11 . 5 . 733–9 . September 2007 . 17563835 . 10.1007/s00792-007-0079-9 .
4. Purification and characterization of glycerate kinase from the thermoacidophilic archaeon Thermoplasma acidophilum: an enzyme belonging to the second glycerate kinase family . Noh, M. . Jung, J.H. . Lee, S.B. . Biotechnol. Bioprocess Eng. . 2006 . 11 . 4 . 344–350 . 10.1007/bf03026251.
5. Yoshida T, Fukuta K, Mitsunaga T, Yamada H, Izumi Y . Purification and characterization of glycerate kinase from a serine-producing methylotroph, Hyphomicrobium methylovorum GM2 . European Journal of Biochemistry . 210 . 3 . 849–54 . December 1992 . 1336459 . 10.1111/j.1432-1033.1992.tb17488.x .
6. Hubbard BK, Koch M, Palmer DR, Babbitt PC, Gerlt JA . Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli . Biochemistry . 37 . 41 . 14369–75 . October 1998 . 9772162 . 10.1021/bi981124f .