Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) explained

glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating)
Ec Number:	1.2.1.59
Cas Number:	39369-25-0
Go Code:	0043891

In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) is an enzyme that catalyzes the chemical reaction

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+

\rightleftharpoons 3-phospho-D-glyceroyl phosphate + NAD(P)H + H⁺

The 4 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, NAD⁺, and NADP⁺, whereas its 4 products are 3-phospho-D-glyceroyl phosphate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating). Other names in common use include (phosphorylating), triosephosphate dehydrogenase (NAD(P)), and glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• P. Mathis (Ed.), Photosynthesis: From Light to Biosphere, vol. 1, Kluwer Academic Publishers, 1995, p. 959-962.
• Valverde F, Losada M, Serrano A . 1997 . Functional complementation of an Escherichia coli gap mutant supports an amphibolic role for NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase of Synechocystis sp. strain PCC 6803 . J. Bacteriol. . 179 . 4513 - 22 . 9226260 . 14 . 10.1128/jb.179.14.4513-4522.1997 . 179286 .