Glutathione amide reductase explained

Glutathione amide reductase
Ec Number:	1.8.1.16

Glutathione amide reductase (GAR) is an enzyme with systematic name glutathione amide:NAD⁺ oxidoreductase.^{[1] [2]} This enzyme catalyses the following chemical reaction

2 glutathione amide + NAD⁺

\rightleftharpoons glutathione amide disulfide + NADH + H⁺

Glutathione amide reductase is a dimeric flavoprotein (FAD).

Notes and References

1. Vergauwen B, Pauwels F, Jacquemotte F, Meyer TE, Cusanovich MA, Bartsch RG, Van Beeumen JJ . Characterization of glutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling . The Journal of Biological Chemistry . 276 . 24 . 20890–7 . June 2001 . 11399772 . 10.1074/jbc.M102026200 . free .
2. Vergauwen B, Van Petegem F, Remaut H, Pauwels F, Van Beeumen JJ . Crystallization and preliminary X-ray crystallographic analysis of glutathione amide reductase from Chromatium gracile . Acta Crystallographica Section D . 58 . Pt 2 . 339–40 . February 2002 . 11807270 . 10.1107/s0907444901020303 .