Glutathione amide-dependent peroxidase explained

Glutathione amide-dependent peroxidase
Ec Number:1.11.1.17

Glutathione amide-dependent peroxidase is an enzyme with systematic name glutathione amide:hydrogen-peroxide oxidoreductase.[1] This enzyme catalyses the following chemical reaction

2 glutathione amide + H2O2

\rightleftharpoons

glutathione amide disulfide + 2 H2O

This enzyme from the proteobacterium Marichromatium gracile is a chimeric protein. It contains a peroxiredoxin-like N-terminus and a glutaredoxin-like C terminus.

Notes and References

  1. Vergauwen B, Pauwels F, Jacquemotte F, Meyer TE, Cusanovich MA, Bartsch RG, Van Beeumen JJ . Characterization of glutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling . The Journal of Biological Chemistry . 276 . 24 . 20890–7 . June 2001 . 11399772 . 10.1074/jbc.M102026200 . free .

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