Glutaryl-CoA dehydrogenase (non-decarboxylating) explained

Glutaryl-CoA dehydrogenase (non-decarboxylating)
Ec Number:	1.3.99.32

Glutaryl-CoA dehydrogenase (non-decarboxylating) (GDHDes, nondecarboxylating glutaryl-coenzyme A dehydrogenase, nondecarboxylating glutaconyl-coenzyme A-forming GDH) is an enzyme with systematic name glutaryl-CoA:acceptor 2,3-oxidoreductase (non-decarboxylating).^{[1] [2]} This enzyme catalyses the following chemical reaction

glutaryl-CoA + acceptor

\rightleftharpoons (E)-glutaconyl-CoA + reduced acceptor

The enzyme contains FAD.

Notes and References

1. Wischgoll S, Taubert M, Peters F, Jehmlich N, von Bergen M, Boll M . Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria . Journal of Bacteriology . 191 . 13 . 4401–9 . July 2009 . 19395484 . 2698508 . 10.1128/JB.00205-09 .
2. Wischgoll S, Demmer U, Warkentin E, Günther R, Boll M, Ermler U . Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases . Biochemistry . 49 . 25 . 5350–7 . June 2010 . 20486657 . 10.1021/bi100317m .