Glutarimide Explained

Glutarimide is the organic compound with the formula (CH2)3(CO)2NH. It is a white solid. The compound forms upon dehydration of the amide of glutaric acid.[1] Glutarimide is sometimes called 2,6-piperidinedione. It is the core of a variety of drugs, including lenalidomide, a medication used to treat anemia and multiple myeloma;[2] and cycloheximide, a potent inhibitor of protein synthesis.[3]

Notes and References

  1. G. . Paris. L.. Berlinguet. R.. Gaudry. J.. English, Jr.. J. E.. Dayan. 10.15227/orgsyn.037.0047. Glutaric Acid and Glutarimide. Organic Syntheses. 1957. 37. 47.
  2. Web site: A to Z List of Cancer Drugs: Lenalidomide. National Cancer Institute . 1 September 2022 . 5 August 2024 .
  3. Book: https://link.springer.com/chapter/10.1007/978-3-642-46051-7_21 . 10.1007/978-3-642-46051-7_21 . Cycloheximide and Other Glutarimide Antibiotics . Mechanism of Action . 1967 . Sisler . Hugh D. . Siegel . Malcolm R. . 283–307 . 978-3-642-46053-1 .

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