Glutamine—fructose-6-phosphate transaminase (isomerizing) explained

glutamine-fructose-6-phosphate transaminase (isomerizing)
Ec Number:2.6.1.16
Cas Number:9030-45-9
Go Code:0004360
Width:270

In enzymology, a glutamine-fructose-6-phosphate transaminase (isomerizing) is an enzyme that catalyzes the chemical reaction

L-glutamine + D-fructose 6-phosphate

\rightleftharpoons

L-glutamate + D-glucosamine 6-phosphate

Thus, the two substrates of this enzyme are L-glutamine and D-fructose 6-phosphate, whereas its two products are L-glutamate and D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:D-fructose-6-phosphate isomerase (deaminating). This enzyme participates in glutamate metabolism and aminosugars metabolism.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,, and .

References