Glutamate N-acetyltransferase explained

glutamate N-acetyltransferase
Ec Number:2.3.1.35
Cas Number:37257-14-0
Go Code:0004358
Altnames:ornithine transacetylase, alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase, acetylglutamate synthetase, acetylglutamate-acetylornithine transacetylase, acetylglutamic synthetase, acetylglutamic-acetylornithine transacetylase, acetylornithinase, acetylornithine glutamate acetyltransferase, glutamate acetyltransferase, N-acetyl-L-glutamate synthetase, N-acetylglutamate synthase, N-acetylglutamate synthetase, ornithine acetyltransferase, 2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase

In enzymology, a glutamate N-acetyltransferase is an enzyme that catalyzes the chemical reaction

N2-acetyl-L-ornithine + L-glutamate

\rightleftharpoons

L-ornithine + N-acetyl-L-glutamate

Thus, the two substrates of this enzyme are N2-acetyl-L-ornithine and L-glutamate, whereas its two products are L-ornithine and N-acetyl-L-glutamate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase. This enzyme participates in the urea cycle and metabolism of amino groups.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and .

References