Glutaconyl-CoA explained

Glutaconyl-CoA is an intermediate in the metabolism of lysine.^[1] It is an organic compound containing a coenzyme substructure, which classifies it as a fatty ester lipid molecule. Being a lipid makes the molecule hydrophobic, which makes it insoluble in water. The molecule has a molecular formula of, and a molecular weight 879.62 grams per mole.^[2]

Glutaconyl-CoA is postulated to be the main toxin in glutaric aciduria type 1.^[3] In certain fermentative bacteria, glutaconyl-CoA decarboxylation is catalyzed by a Na⁺-dependent decarboxylase and is coupled with Na⁺ ion translocation, which creates a sodium-motive force as an alternate energy source for these organisms.^[4]

See also

• Glutaconate CoA-transferase
• Glutaconyl-CoA decarboxylase

References

1. Web site: Glutaryl-CoA Dehydrogenase - an overview . 2022-10-18 . www.sciencedirect.com.
2. Web site: Human Metabolome Database: Showing metabocard for Glutaconyl-CoA (HMDB0001290) . 2022-10-18 . hmdb.ca.
3. Lehnert . Willy . Sass . Jörn Oliver . 2005-01-01 . Glutaconyl-CoA is the main toxic agent in glutaryl-CoA dehydrogenase deficiency (glutaric aciduria type I) . Medical Hypotheses . 65 . 2 . 330–333 . 10.1016/j.mehy.2005.02.021 . 15922108 . 0306-9877.
4. Kress . Daniel . Brügel . Daniela . Schall . Iris . Linder . Dietmar . Buckel . Wolfgang . Essen . Lars-Oliver . October 2009 . An Asymmetric Model for Na+-translocating Glutaconyl-CoA Decarboxylases . Journal of Biological Chemistry . 284 . 41 . 28401–28409 . 10.1074/jbc.m109.037762 . free . 0021-9258 . 2788889 . 19654317.