Glucuronylgalactosylproteoglycan 4-b-N-acetylgalactosaminyltransferase explained

Glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase
Ec Number:	2.4.1.174
Cas Number:	96189-39-8

Glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase (N-acetylgalactosaminyltransferase I, glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I, UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:D-glucuronyl-(1->3)-beta-D-galactosyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan

\rightleftharpoons UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan

This enzyme requires Mn²⁺.

Notes and References

1. Rohrmann K, Niemann R, Buddecke E . Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate . European Journal of Biochemistry . 148 . 3 . 463–9 . May 1985 . 3922754 . 10.1111/j.1432-1033.1985.tb08862.x . free .
2. Uyama T, Kitagawa H, Tamura Ji J, Sugahara K . Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate . The Journal of Biological Chemistry . 277 . 11 . 8841–6 . March 2002 . 11788602 . 10.1074/jbc.M111434200 . free .