Glucuronyl-galactosyl-proteoglycan 4-a-N-acetylglucosaminyltransferase explained
| Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase |
| Ec Number: | 2.4.1.223 |
| Cas Number: | 179241-74-8 |
Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase (alpha-N-acetylglucosaminyltransferase I, alpha1,4-N-acetylglucosaminyltransferase, glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase.[1] [2] This enzyme catalyses the following chemical reaction
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan
UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan
This enzyme is involved in the initiation of heparin and heparan sulfate synthesis.
Notes and References
- Kitagawa H, Shimakawa H, Sugahara K . The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate . The Journal of Biological Chemistry . 274 . 20 . 13933–7 . May 1999 . 10318803 . 10.1074/jbc.274.20.13933 . free .
- Kitagawa H, Egusa N, Tamura JI, Kusche-Gullberg M, Lindahl U, Sugahara K . rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate . The Journal of Biological Chemistry . 276 . 7 . 4834–8 . February 2001 . 11121397 . 10.1074/jbc.C000835200 . free .
