Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase explained
| Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase |
| Ec Number: | 2.4.1.224 |
| Cas Number: | 336193-98-7 |
Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase (alpha-N-acetylglucosaminyltransferase II glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase.[1] [2] [3] [4] This enzyme catalyses the following chemical reaction
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan
UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan
This enzyme is involved in the biosynthesis of heparin and heparan sulfate.
Notes and References
- Kim BT, Kitagawa H, Tamura J, Saito T, Kusche-Gullberg M, Lindahl U, Sugahara K . Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis . Proceedings of the National Academy of Sciences of the United States of America . 98 . 13 . 7176–81 . June 2001 . 11390981 . 34642 . 10.1073/pnas.131188498 . 2001PNAS...98.7176K . free .
- Kitagawa H, Egusa N, Tamura JI, Kusche-Gullberg M, Lindahl U, Sugahara K . rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate . The Journal of Biological Chemistry . 276 . 7 . 4834–8 . February 2001 . 11121397 . 10.1074/jbc.C000835200 . free .
- Senay C, Lind T, Muguruma K, Tone Y, Kitagawa H, Sugahara K, Lidholt K, Lindahl U, Kusche-Gullberg M . The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis . EMBO Reports . 1 . 3 . 282–6 . September 2000 . 11256613 . 1083719 . 10.1093/embo-reports/kvd045 .
- Lind T, Tufaro F, McCormick C, Lindahl U, Lidholt K . The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate . The Journal of Biological Chemistry . 273 . 41 . 26265–8 . October 1998 . 9756849 . 10.1074/jbc.273.41.26265 . free .
