Glucuronate reductase explained

L-glucuronate reductase
Ec Number:	1.1.1.19
Cas Number:	9028-29-9
Go Code:	0047939

In enzymology, a glucuronate reductase is an enzyme that catalyzes the chemical reaction

L-gulonate + NADP⁺

\rightleftharpoons D-glucuronate + NADPH + H⁺

Thus, the two substrates of this enzyme are L-gulonate and NADP⁺, whereas its 3 products are D-glucuronate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-gulonate:NADP⁺ 6-oxidoreductase. Other names in common use include aldehyde reductase, L-hexonate:NADP dehydrogenase, TPN-L-gulonate dehydrogenase, aldehyde reductase II, NADP-L-gulonate dehydrogenase, D-glucuronate dehydrogenase, D-glucuronate reductase, and L-glucuronate reductase (incorrect). This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.

References

• Sivak A, Hoffmann-Ostenhof O . 1961 . Enzymes of mesoinositol catabolism in the yeast Schwanniomyces occidentalis . Biochim. Biophys. Acta . 53 . 426 - 8 . 13913518 . 10.1016/0006-3002(61)90462-0 . 2 .
• Jakoby, W. B. (Ed.), Enzymatic Basis of Detoxication, vol. 1, Academic Press, New York, 1980, p. 249–260.
• York JL, Grollman AP, Bublitz C . 1961 . TPN-L-gluonate dehydrogenase . Biochim. Biophys. Acta . 47 . 298 - 306 . 13787380 . 10.1016/0006-3002(61)90290-6 . 2 .