Glucosylceramide beta-1,4-galactosyltransferase explained
| Glucosylceramide beta-1,4-galactosyltransferase |
| Ec Number: | 2.4.1.274 |
Glucosylceramide beta-1,4-galactosyltransferase (lactosylceramide synthase, uridine diphosphate-galactose:glucosyl ceramide beta 1-4 galactosyltransferase, UDP-Gal:glucosylceramide beta1->4galactosyltransferase, GalT-2, UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase) is an enzyme with systematic name UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase.[1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction
UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide
UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Involved in the synthesis of several different major classes of glycosphingolipids.
Notes and References
- Chatterjee S, Castiglione E . UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes . Biochimica et Biophysica Acta . 923 . 1 . 136–42 . January 1987 . 3099851 . 10.1016/0304-4165(87)90136-X .
- Trinchera M, Fiorilli A, Ghidoni R . Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide beta 1----4galactosyltransferase . Biochemistry . 30 . 10 . 2719–24 . March 1991 . 1900430 . 10.1021/bi00224a021 .
- Chatterjee S, Ghosh N, Khurana S . Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney . The Journal of Biological Chemistry . 267 . 10 . 7148–53 . April 1992 . 10.1016/S0021-9258(19)50550-6 . 1551920 . free .
- Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G, Dohmae N, Takio K, Hattori M, Matsuo N . Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain . The Journal of Biological Chemistry . 273 . 22 . 13570–7 . May 1998 . 9593693 . 10.1074/jbc.273.22.13570 . free .
- Takizawa M, Nomura T, Wakisaka E, Yoshizuka N, Aoki J, Arai H, Inoue K, Hattori M, Matsuo N . cDNA cloning and expression of human lactosylceramide synthase . Biochimica et Biophysica Acta . 1438 . 2 . 301–4 . May 1999 . 10320813 . 10.1016/S1388-1981(99)00051-7 .
