Glucosyl-3-phosphoglycerate synthase explained

Glucosyl-3-phosphoglycerate synthase
Ec Number:2.4.1.266

Glucosyl-3-phosphoglycerate synthase (GpgS protein, GPG synthase, glucosylphosphoglycerate synthase) is an enzyme with systematic name NDP-glucose:3-phospho-D-glycerate 2-alpha-D-glucosyltransferase.[1] [2] [3] [4] [5] [6] This enzyme catalyses the following chemical reaction

NDP-glucose + 3-phospho-D-glycerate

\rightleftharpoons

NDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

The enzyme is involved in biosynthesis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate.

Notes and References

  1. Costa J, Empadinhas N, da Costa MS . Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina . Journal of Bacteriology . 189 . 5 . 1648–54 . March 2007 . 17189358 . 1855766 . 10.1128/JB.00841-06 .
  2. Costa J, Empadinhas N, Gonçalves L, Lamosa P, Santos H, da Costa MS . Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii . Journal of Bacteriology . 188 . 3 . 1022–30 . February 2006 . 16428406 . 1347341 . 10.1128/JB.188.3.1022-1030.2006 .
  3. Empadinhas N, Albuquerque L, Mendes V, Macedo-Ribeiro S, da Costa MS . Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase . FEMS Microbiology Letters . 280 . 2 . 195–202 . March 2008 . 18221489 . 10.1111/j.1574-6968.2007.01064.x . free .
  4. Pereira PJ, Empadinhas N, Albuquerque L, Sá-Moura B, da Costa MS, Macedo-Ribeiro S . Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis . PLOS ONE . 3 . 11 . e3748 . 2008 . 19015727 . 2581804 . 10.1371/journal.pone.0003748 . Song . 2008PLoSO...3.3748P . Haiwei . free .
  5. Gest P, Kaur D, Pham HT, van der Woerd M, Hansen E, Brennan PJ, Jackson M, Guerin ME . Preliminary crystallographic analysis of GpgS, a key glucosyltransferase involved in methylglucose lipopolysaccharide biosynthesis in Mycobacterium tuberculosis . Acta Crystallographica Section F . 64 . Pt 12 . 1121–4 . December 2008 . 19052364 . 2593697 . 10.1107/S1744309108032892 .
  6. Kaur D, Pham H, Larrouy-Maumus G, Rivière M, Vissa V, Guerin ME, Puzo G, Brennan PJ, Jackson M . Initiation of methylglucose lipopolysaccharide biosynthesis in mycobacteria . PLOS ONE . 4 . 5 . e5447 . 2009 . 19421329 . 2674218 . 10.1371/journal.pone.0005447 . 2009PLoSO...4.5447K . Herman . Christophe . free .