Glucose 1-dehydrogenase (NADP+) explained

glucose 1-dehydrogenase (NADP^+)
Ec Number:	1.1.1.119
Cas Number:	37250-50-3
Go Code:	0047935

In enzymology, a glucose 1-dehydrogenase (NADP⁺) is an enzyme that catalyzes the chemical reaction

D-glucose + NADP⁺

\rightleftharpoons D-glucono-1,5-lactone + NADPH + H⁺

Thus, the two substrates of this enzyme are D-glucose and NADP⁺, whereas its 3 products are D-glucono-1,5-lactone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-glucose:NADP⁺ 1-oxidoreductase. Other names in common use include nicotinamide adenine dinucleotide phosphate-linked aldohexose, dehydrogenase, NADP⁺-linked aldohexose dehydrogenase, NADP⁺-dependent glucose dehydrogenase, and glucose 1-dehydrogenase (NADP⁺).

References

• Book: Adachi O . Ameyama M . D-Glucose dehydrogenase from Gluconobacter su☐ydans . 1982 . Carbohydrate Metabolism - Part D . 89 . 159 - 163 . 10.1016/S0076-6879(82)89028-9 . Methods in Enzymology . 978-0-12-181989-7 .
• Avigad G, Alroy Y, Englard S . 1968 . Purification and properties of a nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogeanse from Gluconobacter cerinus . J. Biol. Chem. . 243 . 1936 - 41 . 4384672 . 8 . 10.1016/S0021-9258(18)93531-3 . free .