Glucose 1-dehydrogenase explained
glucose 1-dehydrogenase |
Ec Number: | 1.1.1.47 |
Cas Number: | 9028-53-9 |
Go Code: | 0047936 |
Width: | 270 |
In enzymology, a glucose 1-dehydrogenase is an enzyme that catalyzes the chemical reaction
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H
+The 3 substrates of this enzyme are beta-D-glucose, NAD+, and NADP+, whereas its 4 products are D-glucono-1,5-lactone, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is beta-D-glucose:NAD(P)+ 1-oxidoreductase. Another name in common use is D-glucose dehydrogenase (NAD(P)+).
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,, and .
References
- Banauch D, Brümmer W, Ebeling W, Metz H, Rindfrey H, Lang H, Leybold K, Rick W, Staudinger HJ . 1975 . [A glucose dehydrogenase for the determination of glucose concentrations in body fluids (author's transl)] . Z. Klin. Chem. Klin. Biochem. . 13 . 101 - 7 . 810982 . 3 .
- Brink NG . 1953 . Beef liver glucose dehydrogenase. 1. Purification and properties . Acta Chem. Scand. . 7 . 1081 - 1089 . 10.3891/acta.chem.scand.07-1081 . Miettinen . Jorma K. . Olsen . John . Virtanen . Artturi I. . Sörensen . Nils Andreas . free .
- Pauly HE, Pfleiderer G. 1976 . D-Glucose dehydrogenase from Bacillus megaterium M 1286: purification, properties and structure . Hoppe-Seyler's Z. Physiol. Chem. . 356 . 1613 - 1623 . 2530 . 10 . 10.1515/bchm2.1975.356.2.1613.
- Strecker HJ, Korkes S . 1952 . Glucose dehydrogenase . J. Biol. Chem. . 196 . 769 - 84 . 12981017 . 2 .
- Thompson RE, Carper WR . 1970 . Glucose dehydrogenase from pig liver. I. Isolation and purification . Biochim. Biophys. Acta . 198 . 397 - 406 . 4392298 . 3 . 10.1016/0005-2744(70)90118-x.