Glucose-1-phosphate thymidylyltransferase explained

glucose-1-phosphate thymidylyltransferase
Ec Number:	2.7.7.24
Cas Number:	9026-03-3
Go Code:	0008879
Width:	270

In enzymology, a glucose-1-phosphate thymidylyltransferase is an enzyme that catalyzes the chemical reaction

dTTP + alpha-D-glucose 1-phosphate

\rightleftharpoons diphosphate + dTDP-glucose

Thus, the two substrates of this enzyme are dTTP and alpha-D-glucose 1-phosphate, whereas its two products are pyrophosphate and dTDP-glucose.^[1]

This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.^{[2] [3]}

Nomenclature

The systematic name of this enzyme class is dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase. Other names in common use include:

• glucose 1-phosphate thymidylyltransferase,
• dTDP-glucose synthase, dTDP-glucose pyrophosphorylase,
• thymidine diphosphoglucose pyrophosphorylase,
• thymidine diphosphate glucose pyrophosphorylase, and
• TDP-glucose pyrophosphorylase.

Structural studies

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,,,,,,, and .

Notes and References

1. Samuel G, Reeves P . Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly . Carbohydr. Res. . 338 . 23 . 2503–19 . 2003 . 14670712 . 10.1016/j.carres.2003.07.009.
2. Kornfeld S, Glaser L . The enzymic synthesis of thymidine-linked sugars. I. Thymidine diphosphate glucose . J. Biol. Chem. . 236 . 1791–4 . June 1961 . 13753209 .
3. Pazur JH, Shuey EW . The enzymatic synthesis of thymidine diphosphate glucose and its conversion to thymidine diphosphate rhamnose . J. Biol. Chem. . 236 . 6. 1780–5 . June 1961 . 13733719 .