glucose-1-phosphate thymidylyltransferase | |
Ec Number: | 2.7.7.24 |
Cas Number: | 9026-03-3 |
Go Code: | 0008879 |
Width: | 270 |
In enzymology, a glucose-1-phosphate thymidylyltransferase is an enzyme that catalyzes the chemical reaction
dTTP + alpha-D-glucose 1-phosphate
\rightleftharpoons
Thus, the two substrates of this enzyme are dTTP and alpha-D-glucose 1-phosphate, whereas its two products are pyrophosphate and dTDP-glucose.[1]
This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.[2] [3]
The systematic name of this enzyme class is dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase. Other names in common use include:
As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,,,,,,, and .