Gluconolactonase Explained

gluconolactonase
Ec Number:	3.1.1.17
Cas Number:	9012-73-1
Go Code:	0004341
Width:	270

The enzyme gluconolactonase (EC 3.1.1.17) catalyzes the reaction

D-glucono-1,5-lactone + H₂O

\rightleftharpoons D-gluconate

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is D-glucono-1,5-lactone lactonohydrolase. Other names in common use include lactonase, aldonolactonase, glucono-δ-lactonase, and gulonolactonase. This enzyme participates in three metabolic pathways: pentose phosphate pathway, ascorbate and aldarate metabolism, and caprolactam degradation.

References

• BRODIE AF, LIPMANN F . 1955 . Identification of a gluconolactonase . J. Biol. Chem. . 212 . 677 - 85 . 14353869 . 2 .
• Bublitz C . Lehninger AL . 1961 . The role of aldonolactonase in the conversion of L-gulonate to L-ascorbate . Biochim. Biophys. Acta . 47 . 288 - 297 . 10.1016/0006-3002(61)90289-X . 2 .
• Suzuki K, Kawada M, Shimazono N . Soluble lactonase. Identity of lactonase I and aldonolactonase with gluconolactonase . J. Biochem. . 49 . 448–449 .