Gluconate 2-dehydrogenase explained

gluconate 2-dehydrogenase
Ec Number:	1.1.1.215
Cas Number:	68417-42-5
Go Code:	0008873

In enzymology, a gluconate 2-dehydrogenase is an enzyme that catalyzes the chemical reaction

D-gluconate + NADP⁺

\rightleftharpoons 2-dehydro-D-gluconate + NADPH + H⁺

Thus, the two substrates of this enzyme are D-gluconate and NADP⁺, whereas its 3 products are 2-dehydro-D-gluconate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-gluconate:NADP⁺ oxidoreductase. Other names in common use include 2-keto-D-gluconate reductase, and 2-ketogluconate reductase.

References

• Ameyama M . 1978 . Crystalline 2-ketogluconate reductase from Acetobacter ascendens, the second instance of crystalline enzyme in genus Acetobacter . Agric. Biol. Chem. . 42 . 11 . 2057–2062 . 10.1271/bbb1961.42.2057. free .
• Chiyonobu T, Shinagawa E, Adachi O, Ameyama M . 1976 . Purification, crystallization and properties of 2-ketogluconate reductase from Acetobacter rancens . Agric. Biol. Chem. . 40 . 175 - 184 . 10.1271/bbb1961.40.175. free .