Glucan 1,4-alpha-maltohydrolase explained

Glucan 1,4-alpha-maltohydrolase
Ec Number:3.2.1.133
Cas Number:160611-47-2

Glucan 1,4-alpha-maltohydrolase (maltogenic alpha-amylase, 1,4-alpha-D-glucan alpha-maltohydrolase) is an enzyme with systematic name 4-alpha-D-glucan alpha-maltohydrolase.[1] [2] This enzyme catalyses the following chemical reaction

hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains

This enzyme acts on starch and related polysaccharides and oligosaccharides. Maltogenic amylases from Bacillus stearothermophilus,[3] Thermus sp.[4] and Geobacillus thermoleovorans[5] are able to degrade acarbose to glucose and acarviosine-glucose.

Notes and References

  1. Cloning of a maltogenic α-amylase from Bacillus stearothermophilus . Diderichsen B, Christiansen L . FEMS Microbiol. Lett. . 1988 . 56 . 53–59 . 10.1111/j.1574-6968.1988.tb03149.x. free .
  2. Properties and application of a thermostable maltogenic amylase produced by a strain of Bacillus modified by recombinant-DNA techniques . Outtrup H, Norman BE . Stärke . 1984 . 36 . 12 . 405–411 . 10.1002/star.19840361202.
  3. Cha HJ, Yoon HG, Kim YW, Lee HS, Kim JW, Kweon KS, Oh BH, Park KH . 6 . Molecular and enzymatic characterization of a maltogenic amylase that hydrolyzes and transglycosylates acarbose . European Journal of Biochemistry . 253 . 1 . 251–262 . April 1998 . 9578484 . 10.1046/j.1432-1327.1998.2530251.x . free .
  4. Kim TJ, Kim MJ, Kim BC, Kim JC, Cheong TK, Kim JW, Park KH . Modes of action of acarbose hydrolysis and transglycosylation catalyzed by a thermostable maltogenic amylase, the gene for which was cloned from a Thermus strain . EN . Applied and Environmental Microbiology . 65 . 4 . 1644–1651 . April 1999 . 10103262 . 10.1128/AEM.65.4.1644-1651.1999 . 91232 . 1999ApEnM..65.1644K .
  5. Mehta D, Satyanarayana T . Dimerization mediates thermo-adaptation, substrate affinity and transglycosylation in a highly thermostable maltogenic amylase of Geobacillus thermoleovorans . PLOS ONE . 8 . 9 . e73612 . 2013-09-19 . 24069213 . 3777949 . 10.1371/journal.pone.0073612 . 2013PLoSO...873612M . free .

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