Glucan 1,4-α-glucosidase explained

Glucan 1,4-α-glucosidase
Ec Number:	3.2.1.3
Cas Number:	9032-08-0
Width:	270

Glucan 1,4-α-glucosidase (glucoamylase, amyloglucosidase', γ-amylase, lysosomal α-glucosidase, acid maltase, exo-1,4-α-glucosidase, glucose amylase, γ-1,4-glucan glucohydrolase, acid maltase, 1,4-α-D-glucan glucohydrolase) is an enzyme located on the brush border of the small intestine with systematic name 4-α-D-glucan glucohydrolase.^{[1] [2] [3] [4] [5] [6]} It catalyses the following chemical reaction

Hydrolysis of terminal (1→4)-linked α-D-glucose residues successively from non-reducing ends of the chains with release of β-D-glucose

Most forms of the enzyme can rapidly hydrolyse 1,6-α-D-glucosidic bonds when the next bond in the sequence is 1,4. They belong to a variety of different families, such as glycoside hydrolase family 15 in fungi, glycoside hydrolase family 31 of human intestine MGAM, and glycoside hydrolase family 97 of bacterial forms. It was also known as γ-amylase.

See also

• Amylase

Notes and References

1. French D, Knapp DW . The maltase of Clostridium acetobutylicum; its specificity range and mode of action . The Journal of Biological Chemistry . 187 . 2 . 463–71 . December 1950 . 10.1016/S0021-9258(18)56190-1 . 14803428 . free .
2. Brown BI, Brown DH . The subcellular distribution of enzymes in type II glycogenosis and the occurrence of an oligo-α-1,4-glucan glucohydrolase in human tissues . Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation . 110 . 1 . 124–33 . October 1965 . 4286143 . 10.1016/s0926-6593(65)80101-1 .
3. Jeffrey PL, Brown DH, Brown BI . Studies of lysosomal α-glucosidase. I. Purification and properties of the rat liver enzyme . Biochemistry . 9 . 6 . 1403–15 . March 1970 . 4313883 . 10.1021/bi00808a015 .
4. Kelly JJ, Alpers DH . Properties of human intestinal glucoamylase . Biochimica et Biophysica Acta (BBA) - Enzymology . 315 . 1 . 113–22 . July 1973 . 4743896 . 10.1016/0005-2744(73)90135-6 .
5. Copeland WH, Miller KD . A blood trans-α-glucosylase . Biochimica et Biophysica Acta . 22 . 1 . 193–4 . October 1956 . 13373867 . 10.1016/0006-3002(56)90242-6 .
6. Tsujisaka Y, Fukumoto J, Yamamcto T . Specificity of crystalline saccharogenic amylase of moulds . Nature . 181 . 4611 . 770–1 . March 1958 . 13517301 . 10.1038/181770a0 . 1958Natur.181..770T . 2810440 .