Alpha-glucan, water dikinase explained

alpha-glucan, water dikinase
Ec Number:	2.7.9.4
Cas Number:	664327-94-0
Go Code:	0050521

In enzymology, an alpha-glucan, water dikinase is an enzyme that catalyzes the chemical reaction

ATP + alpha-glucan + H₂O

\rightleftharpoons AMP + phospho-alpha-glucan + phosphate

The 3 substrates of this enzyme are ATP, alpha-glucan, and H₂O, whereas its 3 products are AMP, phospho-alpha-glucan, and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with paired acceptors (dikinases). The systematic name of this enzyme class is ATP:alpha-glucan, water phosphotransferase. This enzyme is also called starch-related R1 protein, GWD.

References

• Ritte G, Lloyd JR, Eckermann N, Rottmann A, Kossmann J, Steup M . 2002 . The starch-related R1 protein is an alpha -glucan, water dikinase . Proc. Natl. Acad. Sci. U.S.A. . 99 . 7166 - 71 . 12011472 . 10.1073/pnas.062053099 . 10 . 124546 . 2002PNAS...99.7166R . free .
• Ritte G, Heydenreich M, Mahlow S, Haebel S, Kotting O, Steup M . 2006 . Phosphorylation of C6- and C3-positions of glucosyl residues in starch is catalysed by distinct dikinases . FEBS Lett. . 580 . 4872 - 6 . 16914145 . 10.1016/j.febslet.2006.07.085 . 20 .