Glovadalen Explained

Glovadalen (developmental code name UCB-0022) is a dopamine D1 receptor positive allosteric modulator which is under development for the treatment of Parkinson's disease.[1] [2] [3] [4] [5] [6] It has been found to potentiate the capacity of dopamine to activate the D1 receptor by 10-fold in vitro with no actions on other dopamine receptors. As of May 2024, glovadalen is in phase 2 clinical trials for this indication. The drug is under development by UCB Biopharma. It is described as an orally active, centrally penetrant small molecule.

See also

Notes and References

  1. Web site: UCB 0022 . AdisInsight . Springer Nature Switzerland AG . 28 May 2024 . 10 August 2024.
  2. Web site: Delving into the Latest Updates on Glovadalen with Synapse . Synapse . 8 August 2024 . 10 August 2024.
  3. McFarthing K, Buff S, Rafaloff G, Fiske B, Mursaleen L, Fuest R, Wyse RK, Stott SR . Parkinson's Disease Drug Therapies in the Clinical Trial Pipeline: 2023 Update . Journal of Parkinson's Disease . 13 . 4 . 427–439 . 2023 . 37302040 . 10357160 . 10.3233/JPD-239901 . Our analysis of dopaminergic therapies shows a continued emphasis on DA agonists and levodopa reformulation. These include Cerevel's tavapadon, a D1/D5 receptor partial agonist and UCB0022, a positive allosteric modulator of the D1 receptor, as well as approaches to sub-cutaneously deliver levodopa/carbidopa such as Abbvie's ABBV-951 and Neuroderm's ND0612. .
  4. Web site: Glovadalen . IUPHAR/BPS Guide to PHARMACOLOGY . 10 August 2024.
  5. Web site: UCB0022 . ALZFORUM . 3 May 2024 . 10 August 2024.
  6. Vermeiren C, Ates A, Bouzom F, Delaunois A, Gillard M, Kenda B, Ousset A, Provins L, Skolc D, Valade A, Vanmeulder M, Wood M, Lamberty Y . Preclinical characterization of UCB0022, an oral, brain penetrant, selective, clinical-stage positive allosteric modulator of the dopamine 1 receptor (D1 PAM) . Movement Disorders . 37 . Suppl 2 [2022 International Congress September 15-18, 2022. Madrid, Spain] . 7 September 2022 . 10 August 2024.

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