Geranylgeranylglycerol-phosphate geranylgeranyltransferase explained

geranylgeranylglycerol-phosphate geranylgeranyltransferase
Ec Number:	2.5.1.42
Cas Number:	124650-68-6
Go Code:	0047295

In enzymology, a geranylgeranylglycerol-phosphate geranylgeranyltransferase is an enzyme that catalyzes the chemical reaction

geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate

\rightleftharpoons diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate

Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and sn-3-O-(geranylgeranyl)glycerol 1-phosphate, whereas its two products are diphosphate and 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl groups or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase. Other names in common use include geranylgeranyloxyglycerol phosphate geranylgeranyltransferase, and geranylgeranyltransferase II.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

References

• Zhang DL, Daniels L, Poulter CD . 1990 . Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction . J. Am. Chem. Soc. . 112 . 1264 - 1265 . 10.1021/ja00159a067 . 3 .