Geranylgeranyl diphosphate reductase explained

Geranylgeranyl diphosphate reductase
Ec Number:	1.3.1.83

Geranylgeranyl diphosphate reductase (geranylgeranyl reductase, CHL P) is an enzyme with systematic name geranylgeranyl-diphosphate:NADP⁺ oxidoreductase.^{[1] [2] [3]} This enzyme catalises the following chemical reaction

phytyl diphosphate + 3 NADP⁺

\rightleftharpoons geranylgeranyl diphosphate + 3 NADPH + 3 H⁺

This enzyme also acts on geranylgeranyl-chlorophyll a.

Notes and References

1. Soll J, Schultz G, Rüdiger W, Benz J . Hydrogenation of geranylgeraniol : two pathways exist in spinach chloroplasts . Plant Physiology . 71 . 4 . 849–54 . April 1983 . 16662918 . 1066133 . 10.1104/pp.71.4.849 .
2. Tanaka R, Oster U, Kruse E, Rudiger W, Grimm B . Reduced activity of geranylgeranyl reductase leads to loss of chlorophyll and tocopherol and to partially geranylgeranylated chlorophyll in transgenic tobacco plants expressing antisense RNA for geranylgeranyl reductase . Plant Physiology . 120 . 3 . 695–704 . July 1999 . 10398704 . 59307 . 10.1104/pp.120.3.695 .
3. Keller Y, Bouvier F, d'Harlingue A, Camara B . Metabolic compartmentation of plastid prenyllipid biosynthesis--evidence for the involvement of a multifunctional geranylgeranyl reductase . European Journal of Biochemistry . 251 . 1-2 . 413–7 . January 1998 . 9492312 . 10.1046/j.1432-1327.1998.2510413.x . free .