Geranyl-pyrophosphate—olivetolic acid geranyltransferase explained

Geranyl-pyrophosphate—olivetolic acid geranyltransferase
Ec Number:2.5.1.102

Geranyl-pyrophosphate—olivetolic acid geranyltransferase (GOT) is an enzyme with systematic name geranyl-diphosphate:olivetolate geranyltransferase.[1] This enzyme catalyses the following chemical reaction

geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate

\rightleftharpoons

diphosphate + cannabigerolate

Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa.

Notes and References

  1. Fellermeier M, Zenk MH . Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol . FEBS Letters . 427 . 2 . 283–5 . May 1998 . 9607329 . 10.1016/S0014-5793(98)00450-5 . free .