Gem-associated protein 5 explained

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.^{[1] [2]}

Function

Gem-associated protein 5 is part of the SMN a large protein complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), gem-associated protein 2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).

Interactions

GEMIN5 has been shown to interact with DDX20^{[1] [3]} and SMN1.^[1]

Further reading

• Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G . Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex . J. Biol. Chem. . 277 . 35 . 31957–62 . 2002 . 12065586 . 10.1074/jbc.M203478200 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Battle DJ, Lau CK, Wan L, Deng H, Lotti F, Dreyfuss G . The Gemin5 protein of the SMN complex identifies snRNAs . Mol. Cell . 23 . 2 . 273–9 . 2006 . 16857593 . 10.1016/j.molcel.2006.05.036 . free .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Kim EK, Noh KT, Yoon JH, Cho JH, Yoon KW, Dreyfuss G, Choi EJ . Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5 . Cell Death Differ. . 14 . 8 . 1518–28 . 2007 . 17541429 . 10.1038/sj.cdd.4402157 . free .
• Hao le T, Fuller HR, Lam le T, Le TT, Burghes AH, Morris GE . Absence of gemin5 from SMN complexes in nuclear Cajal bodies . BMC Cell Biol. . 8 . 28 . 2007 . 17640370 . 1939999 . 10.1186/1471-2121-8-28 . free .
• Battle DJ, Kasim M, Wang J, Dreyfuss G . SMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediate . J. Biol. Chem. . 282 . 38 . 27953–9 . 2007 . 17640873 . 10.1074/jbc.M702317200 . free .

Notes and References

1. Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G . Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins . J Biol Chem . 277 . 7 . 5631–6 . Feb 2002 . 11714716 . 10.1074/jbc.M109448200 . free .
2. Web site: Entrez Gene: GEMIN5 gem (nuclear organelle) associated protein 5.
3. Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G . miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs . Genes Dev. . 16 . 6 . 720–8 . Mar 2002 . 11914277 . 155365 . 10.1101/gad.974702 .