Gaseous mediator explained

Gaseous mediators are chemicals that are produced in small amounts by some cells of the mammalian body and have a number of biological signalling functions. There are three so-far-identified gaseous mediator molecules: nitric oxide (NO), hydrogen sulfide (H₂S), and carbon monoxide (CO).^[1]

Clinical Applications

Endogenous gaseous mediators have shown anti-inflammatory and cytoprotective properties^[2] Combination nonsteroidal anti-inflammatory drugs featuring both a cyclooxygenase inhibitor and gaseous mediator releasing component are being investigated as a safer alternative to current anti-inflammatory drugs^[3] due to their potential reduction in risk for gastrointestinal ulcer formation.^[4]

Notes and References

1. 1363746 . 16467393 . 10.1152/japplphysiol.00793.2005 . 100 . 3 . Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation . March 2006 . J. Appl. Physiol. . 1065–76. Leffler . C. W. . Parfenova . H . Jaggar . J. H. . Wang . R .
2. Rodrigues. L.. Ekundi-Valentim. E.. Florenzano. J.. Cerqueira. A. R. A.. Soares. A. G.. Schmidt. T. P.. Santos. K. T.. Teixeira. S. A.. Ribela. M. T. C. P.. Rodrigues. S. F.. de Carvalho. M. H.. 2017-01-01. Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice. Pharmacological Research. en. 115. 255–266. 10.1016/j.phrs.2016.11.006. 27840098 . 1043-6618. 10871/24576. 1165855 . free.
3. Sulaieva. Oksana. Wallace. John L. 2015-12-01. Gaseous mediator-based anti-inflammatory drugs. Current Opinion in Pharmacology. Gastrointestinal • Endocrine and metabolic diseases. en. 25. 1–6. 10.1016/j.coph.2015.08.005. 1471-4892.
4. Web site: New strategy for gastrointestinal protection based on gaseous mediators application. Sulaieva. O. N.. Wallace. J. L.. 2016. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2020-04-27.