| gamma-glutamylcyclotransferase | |
| Ec Number: | 2.3.2.4 |
| Cas Number: | 9045-44-7 |
| Go Code: | 0003839 |
In enzymology, a gamma-glutamylcyclotransferase is an enzyme that catalyzes the chemical reaction
(5-L-glutamyl)-L-amino acid
\rightleftharpoons
Hence, this enzyme has one substrate, (5-L-glutamyl)-L-amino acid, and two products, 5-oxoproline and L-amino acid.
This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is (5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing). Other names in common use include gamma-glutamyl-amino acid cyclotransferase, gamma-L-glutamylcyclotransferase, and L-glutamic cyclase. This enzyme participates in glutathione metabolism.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .