Gamma-D-Glutamyl-meso-diaminopimelate peptidase explained
| Gamma-D-glutamyl-meso-diaminopimelate peptidase |
| Ec Number: | 3.4.19.11 |
| Cas Number: | 62572-28-5 |
Gamma-D-glutamyl-meso-diaminopimelate peptidase (endopeptidase I, gamma-D-glutamyldiaminopimelate endopeptidase, gamma-D-glutamyl-L-meso-diaminopimelate peptidoglycan hydrolase, gamma-glutamyl-L-meso-diaminopimelyl endopeptidase, gamma-D-glutamyl-meso-diaminopimelate endopeptidase, gamma-D-glutamyl-meso-diaminopimelic peptidoglycan hydrolase, gamma-D-glutamyl-meso-diaminopimelic endopeptidase, gamma-D-glutamyl-meso-D-aminopimelic endopeptidase) is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction
Hydrolysis of gamma-D-glutamyl bonds to the L-terminus (position 7) of meso-diaminopimelic acid (meso-A2pm) in 7-(L-Ala-gamma-D-Glu)-meso-A2pm and 7-(L-Ala-gamma-D-Glu)-7-(D-Ala)-meso-A2pm. It is required that the D-terminal amino and carboxy groups of meso-A2pm are unsubstituted
This metallopeptidase is isolate from Bacillus sphaericus.
Notes and References
- Arminjon F, Guinand M, Vacheron MJ, Michel G . Specificity profiles of the membrane-bound gamma-D-glutamyl-(L)meso-diaminopimelateendopeptidase and LD-carboxypeptidase from Bacillus sphaericus 9602 . European Journal of Biochemistry . 73 . 2 . 557–65 . March 1977 . 849747 . 10.1111/j.1432-1033.1977.tb11351.x .
- Garnier M, Vacheron MJ, Guinand M, Michel G . Purification and partial characterization of the extracellular gamma-D-glutamyl-(L)meso-diaminopimelate endopeptidase I, from Bacillus sphaericus NCTC 9602 . European Journal of Biochemistry . 148 . 3 . 539–43 . May 1985 . 3922755 . 10.1111/j.1432-1033.1985.tb08873.x . free .
- Hourdou ML, Guinand M, Vacheron MJ, Michel G, Denoroy L, Duez C, Englebert S, Joris B, Weber G, Ghuysen JM . Characterization of the sporulation-related gamma-D-glutamyl-(L)meso-diaminopimelic-acid-hydrolysing peptidase I of Bacillus sphaericus NCTC 9602 as a member of the metallo(zinc) carboxypeptidase A family. Modular design of the protein . The Biochemical Journal . 292 . 563–70 . June 1993 . 8503890 . 1134247 . 2 . 10.1042/bj2920563.
