Galegine Explained

Galegine is a toxic chemical compound that has been isolated from Galega officinalis.[1] It has also been found to be the principal cause of the toxicity of poison sedge (Schoenus asperocarpus).[2]

Galegine was used in the 1920s as a pharmaceutical treatment for diabetes;[3] however, because of its toxicity, its use was soon supplanted by superior alternatives. Research on galegine eventually led to the development of metformin which is used today for treatment of type 2 diabetes.[3]

See also

Notes and References

  1. 10.1614/WS-D-10-00169.1. Galegine Content in Goatsrue (Galega officinalis) Varies by Plant Part and Phenological Growth Stage. Weed Science. 59. 3. 349–352. 2011. Oldham. Michelle. Ransom. Corey V.. Ralphs. Michael H.. Gardner. Dale R..
  2. 8343085 . 1993 . Huxtable . C. R. . Identification of galegine, an isoprenyl guanidine, as the toxic principle of Schoenus asperocarpus (poison sedge) . Australian Veterinary Journal . 70 . 5 . 169–71 . Dorling . P. R. . Colegate . S. M. . 10.1111/j.1751-0813.1993.tb06120.x .
  3. 10.1002/pdi.606. Metformin: Its botanical background. Practical Diabetes International. 21. 3. 115–117. 2004. Bailey. CJ. Day. C.. free.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Galegine".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.