Galactosyldiacylglycerol alpha-2,3-sialyltransferase explained
| galactosyldiacylglycerol alpha-2,3-sialyltransferase |
| Ec Number: | 2.4.99.5 |
| Cas Number: | 80237-98-5 |
| Go Code: | 0047289 |
In enzymology, a galactosyldiacylglycerol alpha-2,3-sialyltransferase is an enzyme that catalyzes the chemical reaction
CMP-N-acetylneuraminate + 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol
CMP + 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn- glycerol
Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol, whereas its 3 products are CMP, 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-, and glycerol.
This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase. This enzyme participates in glycerolipid metabolism.
References
- Pieringer J, Keech S, Pieringer RA . 1981 . Biosynthesis in vitro of sialosylgalactosyldiacylglycerol by mouse brain microsomes . J. Biol. Chem. . 256 . 12306 - 9 . 7298658 . 23 .
- Weinstein J, de Souza-e-Silva U, Paulson JC . 1982 . Purification of a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase and a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase to homogeneity from rat liver . J. Biol. Chem. . 257 . 13835 - 44 . 7142179 . 22 .
- Weinstein J, de Souza-e-Silva U, Paulson JC . 1982 . Sialylation of glycoprotein oligosaccharides N-linked to asparagine Enzymatic characterization of a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase and a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase from rat liver . J. Biol. Chem. . 257 . 13845 - 53 . 7142180 . 22 .
