| Galactoside O-acetyltransferase | |
| Ec Number: | 2.3.1.18 |
| Cas Number: | 9029-94-1 |
| Go Code: | 0008870 |
| Thiogalactoside acetyltransferase | |
| Organism: | Escherichia coli |
| Taxid: | 511145 |
| Symbol: | lacA |
| Entrezgene: | 945674 |
| Refseqprotein: | NP_414876 |
| Uniprot: | P07464 |
Galactoside acetyltransferase (also known as Galactoside O-acetyltransferase, thiogalactoside transacetylase, β-galactoside transacetylase and GAT) is an enzyme that transfers an acetyl group from acetyl-CoA to β-galactosides, glucosides and lactosides. It is coded for by the lacA gene of the lac operon in E. coli.[1]
It catalyzes the following reaction:
acetyl-CoA + beta-D-galactoside → CoA + 6-acetyl-beta-D-galactoside
The kinetics of the enzyme were delineated in 1995.[2]
The enzyme's role in the classical E.coli lac operon remains unclear.[3] However, the enzyme's cellular role may be to detoxify non-metabolizable pyranosides by acetylating them and preventing their reentry into the cell.[1] [4]