3-Galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase explained

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase
Ec Number:2.4.1.65
Cas Number:37277-69-3
Go Code:0017060

In enzymology, a 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R

\rightleftharpoons

GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D- glucosaminyl-R

Thus, the two substrates of this enzyme are GDP-beta-L-fucose and beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R, whereas its 3 products are GDP, beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-, and glucosaminyl-R.

This enzyme participates in 3 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, and glycan structures - biosynthesis 2.

Nomenclature

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase. Other names in common use include:

References

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "3-Galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.